Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. I. Biologic, Genetic, and Biochemical Characterization
Identifieur interne : 002797 ( Main/Exploration ); précédent : 002796; suivant : 002798Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. I. Biologic, Genetic, and Biochemical Characterization
Auteurs : P. Reeve [Autriche, États-Unis, Royaume-Uni] ; J. W. Almond [Autriche, États-Unis] ; V. Felsenreich [Autriche, États-Unis] ; M. Pibermann [Autriche, États-Unis] ; H. F. Maassab [Autriche, États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1980.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Antigènes viraux.
- génétique : ARN viral, Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- Animaux, Basse température, Embryon de poulet, Mutation, Recombinaison génétique, Sous-type H3N2 du virus de la grippe A, Variation génétique.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antigens, Viral.
- genetics : Influenza A virus, RNA, Viral.
- immunology : Influenza A virus, Influenza Vaccines.
- Animals, Chick Embryo, Cold Temperature, Genetic Variation, Influenza A Virus, H3N2 Subtype, Mutation, Recombination, Genetic.
Abstract
A cold-recombinant virus, CR 22, was derived from an attenuated cold-adapted parent strain, AIAnn Arbor/6/60 (H2N2), and a wild-type parent strain, A/Victoria/3/75 (H3N2). Antigenic analysis showed that CR 22 possesses the hemagglutinin and neuraminidase surface antigens derived from the A/Victoria/3/75 (H3N2) parent. From studies of virus-induced polypeptides using polyacrylamide gel electrophoresis, it was deduced that a polymerase protein, PI, is coded for by an RNA segment derived from the wild-type parent; all other genetic elements are derived from the attenuated parent. The attenuated parent and the recombinant CR 22 both possess temperature-sensitive (ts) lesions, evident by restriction of multiplication in fertile chicken eggs or in MadinDarby canine kidney cell cultures at ⩾38 C. Genetic analysis of CR 22 by complementation tests using Hong Kong and Wilson Smith neurotropic ts mutants gave evidence for a ts lesion in the genetic elements coding for complementary RNA.
Url:
DOI: 10.1093/infdis/142.6.850
Affiliations:
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I. Biologic, Genetic, and Biochemical Characterization</title><author><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3</wicri:cityArea></affiliation></author><author><name sortKey="Almond, J W" sort="Almond, J W" uniqKey="Almond J" first="J. W." last="Almond">J. W. Almond</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Felsenreich, V" sort="Felsenreich, V" uniqKey="Felsenreich V" first="V." last="Felsenreich">V. Felsenreich</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Pibermann, M" sort="Pibermann, M" uniqKey="Pibermann M" first="M." last="Pibermann">M. Pibermann</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1980-12">1980</date><biblScope unit="vol">142</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="850">850</biblScope><biblScope unit="page" to="856">856</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Viral (analysis)</term><term>Chick Embryo</term><term>Cold Temperature</term><term>Genetic Variation</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Mutation</term><term>RNA, Viral (genetics)</term><term>Recombination, Genetic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Animaux</term><term>Antigènes viraux (analyse)</term><term>Basse température</term><term>Embryon de poulet</term><term>Mutation</term><term>Recombinaison génétique</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccins antigrippaux (immunologie)</term><term>Variation génétique</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chick Embryo</term><term>Cold Temperature</term><term>Genetic Variation</term><term>Influenza A Virus, H3N2 Subtype</term><term>Mutation</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Embryon de poulet</term><term>Mutation</term><term>Recombinaison génétique</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">A cold-recombinant virus, CR 22, was derived from an attenuated cold-adapted parent strain, AIAnn Arbor/6/60 (H2N2), and a wild-type parent strain, A/Victoria/3/75 (H3N2). Antigenic analysis showed that CR 22 possesses the hemagglutinin and neuraminidase surface antigens derived from the A/Victoria/3/75 (H3N2) parent. From studies of virus-induced polypeptides using polyacrylamide gel electrophoresis, it was deduced that a polymerase protein, PI, is coded for by an RNA segment derived from the wild-type parent; all other genetic elements are derived from the attenuated parent. The attenuated parent and the recombinant CR 22 both possess temperature-sensitive (ts) lesions, evident by restriction of multiplication in fertile chicken eggs or in MadinDarby canine kidney cell cultures at ⩾38 C. Genetic analysis of CR 22 by complementation tests using Hong Kong and Wilson Smith neurotropic ts mutants gave evidence for a ts lesion in the genetic elements coding for complementary RNA.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Michigan</li><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name></region><name sortKey="Almond, J W" sort="Almond, J W" uniqKey="Almond J" first="J. W." last="Almond">J. W. Almond</name><name sortKey="Felsenreich, V" sort="Felsenreich, V" uniqKey="Felsenreich V" first="V." last="Felsenreich">V. Felsenreich</name><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><name sortKey="Pibermann, M" sort="Pibermann, M" uniqKey="Pibermann M" first="M." last="Pibermann">M. Pibermann</name></country><country name="États-Unis"><region name="Michigan"><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name></region><name sortKey="Almond, J W" sort="Almond, J W" uniqKey="Almond J" first="J. W." last="Almond">J. W. Almond</name><name sortKey="Felsenreich, V" sort="Felsenreich, V" uniqKey="Felsenreich V" first="V." last="Felsenreich">V. Felsenreich</name><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><name sortKey="Pibermann, M" sort="Pibermann, M" uniqKey="Pibermann M" first="M." last="Pibermann">M. Pibermann</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. 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